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Biochemistry MCQS PAPER SET 6
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1. Which of the following can be diagnosed by amniocentesis?
Down's syndrome
Cystic Fibrosis
Sickle cell anemia
All of these
2. Fructose is metabolized by
fructose 1-phosphate pathway
fructose 6-phosphate pathway
glyceraldehyde 3-phosphate pathway
both (a) and (b)
3. A common way that cells capture the energy released during the breakdown of large molecules is to add electrons to smaller, specialized molecules that can accept them. This process of electron acceptance is otherwise known as
biosynthesis
metabolism
reduction
catalysis
4. Humans are unable to digest
starch
complex carbohydrates
denatured proteins
cellulose
5. How many ATP equivalents per mole of glucose input are required for gluconeogenesis?
2
6
8
4
6. Which of the following compounds is responsible for coordinated regulation of glucose and glycogen metabolism?
NAD+
Fructose 2,6 bisphosphate
Acetyl-CoA
Fructose 1,6 bisphosphate
7. Gluconeogenesis requires a higher amount of ATP equivalents as compared to that produced by glycolysis because
gluconeogenesis releases energy as heat
glycolysis releases energy as heat
glycolysis occurs in the mitochondria while gluconeogenesis occurs in the cytosol
all of the above
8. Which of the following is carried out when cAMP functions as a second messenger?
Acts second in importance to AMP
Activates all cytosolic protein kinases
Activates the cAMP-dependent protein kinase
Acts outside the cell to influence cellular processes
9. The production or break down of __________ is often coupled with the metabolic reactions of biosynthesis and catabolism.
aspirin
DNA
ATP
CO2
10. The cells dependent solely on glucose as an energy source are
muscle cells
brain cells
kidney cells
liver cells
11. The main site for gluconeogenesis is
kidney
liver
brain
muscle
12. Which of the following statements about the energy needs of cells is false?
Without a continuous input of energy, cell disorder will increase
The laws of thermodynamics force cells to acquire energy
Many cellular reactions have an associated activation energy
The most usable energy for cells comes from the rapid combustion of glucos
13. In lysozyme catalysis, which of the following does not contribute?
The abnormally high pKa of Glu35
The strained conformation of the D sugar
Formation of a covalent intermediate at Asp52
Formation of a covalent intermediate at Ser195
14. Cellulose fibers resemble with the protein structure in the form of
β-sheets
α-helices
β-turns
None of these
15. During vigorous exercise, pyruvate produced by glycolysis is converted to
acetate
lactate
monosodium phosphate
pyruvic acid
16. Glucagon and epinephrine
inhibits gluconeogenesis and stimulates glycolysis
stimulates gluconeogenesis and glycolysis
stimulates gluconeogenesis and inhibits glycolysis
inhibits gluconeogenesis and glycolysis
17. The NAG6 substrate is hydrolyzed by human lysozyme to form
6 glucosamines + 6 acetic acids
NAG4 + NAG2
NAG3 + NAG3
NAG3
18. Gluconeogenesis uses
3 ATPs and 2 GTPs per glucose
2 ATPs and 1 GTPs per glucose
3 ATPs and 3 GTPs per glucose
4 ATPs and 2 GTPs per glucose
19. Saliva contains all of the following except
hormones
amylase
bacteria-killing enzymes
antibodies
20. The conversion of pyruvate to oxaloacetate
requires biotin
involves the fixation of carbon dioxide
occurs in the mitochondria
all of the above
21. Gluconeogenesis is the
formation of glycogen
breakdown of glucose to pyruvate
breakdown of glycogen to glucose
synthesis of glucose from non-carbohydrate precursors
22. Hydrolysis of lactose yields
galactose and fructose
galactose and glucose
glucose and fructose
fructose and galactose
23. Two major products of pentose phosphate pathway are
nicotinamide adenine dinucleotide and ribose 5-phosphate
flavine adenine dinuclueotide and glucose 5-phosphate
FAD and CoA
NADPH and NAD
24. A catabolic intermediate which stimulates phosphofructokinase would stimulate
gluconeogenesis
glycolysis
glycogen synthesis
none of these
25. Pyruvate is initially converted to which of the following in the gluconeogenesis?
Glycerol
Phosphoenol pyruvate
Oxaloacetate
Acetyl CoA
26. Boat and chair conformations are found
in pyranose sugars
in any sugar without axial -OH groups
in any sugar without equatorial -OH groups
only in D-glucopyranose
27. The conversion of pyruvate to lactate is catalysed by
pyruvate carboxylase
lactate dehydrogenase
pyruvate dismutase
pyruvate decarboxylase
28. Which of the following can act as precursors for gluconeogenesis?
Lactate
Glycerol
Alanine
All of these
29. a-amylose is similar to
β-sheets
β-turned coils
α-helices
the hydrophobic core
30. Storage polysaccharide made by animals is
amylopectin
glycogen
cellulose
collagen
31. The glycosidic bond
in maltose is not hydrolyzed in lactose intolerant humans
in sucrose is hydrolyzed by bees
joins glucose and fructose to form sucrose
both b and c
32. The sugar which forms major component of nucleic acids is
ribose
galactose
mannose
maltose
33. Under aerobic condition pyruvate is converted by pyruvate dehydrogenase to
phosphoenol pyruvate
acetyl CoA
lactate
glyceraldehyde 3 phosphate
34. Which of the following is not a disaccharide?
Amylose
Cellobiose
Lactose
None of these
35. Hexokinase activity in glycolysis is inhibited by
glucose 6- phosphate
fructose 6-phosphate
fructose 1,6 biphosphate
phosphofructokinase
36. The ultimate source of energy that sustains living systems is
glucose
oxygen
sunlight
carbon dioxide
37. Citric acid accumulation would
stimulate phosphofructokinase activity
stimulate fructose 1,6 diphosphatase activity
inhibit phosphofructokinase activity
both (b) and (c)
38. Which of the following is not involved in the biosynthesis of DNA?
Energy from ATP
Mononucleotides
Carbonic anhydrase
Enzymes
39. Which of the following would be considered a part of metabolism?
Biosynthetic pathways that build DNA
Catabolic pathways that break down complex carbohydrates
The capture of light energy for use in making glucose
All of the above
40. Insulin
stimulates gluconeogenesis and glycolysis
stimulates gluconeogenesis and inhibits glycolysis
inhibits gluconeogenesis and glycolysis
inhibits gluconeogenesis and stimulates glycolysis
41. What is present in the stomach to prevent self-digestion?
Mucus
acid
Enzymes
hormones
42. The key enzyme in the regulation of fatty acid synthesis is
acetyl CoA carboxylase
AMP activated proteinkinase
protein phosphatase
none of these
43. In the intestine, the dietary fats are hydrolysed by
triacylglycerol lipase
adenylate cyclase
pancreatic lipase
protein kinase
44. HDLs are synthesized in
blood
liver
intestine
pancreas
45. Triacylglycerols are
soluble in water
insoluble in water
soluble in water at elevated temperature
partially soluble in water
46. Animals cannot convert fatty acids into glucose because
acetyl CoA can not be converted to pyruvate
absence of malate synthase
absence of dehydrogenase
absence of a-ketoglutarate dehydrogenase
47. What is the major protein constituent of high-density lipoprotein (HDL)?
Apolipoprotein A-l
Apolipoprotein C-l
Apolipoprotein E
None of these
48. Phospholipid contains
hydrophilic heads and hydrophobic tails
long water-soluble carbon chains
positively charged functional groups
both (b) and ( c)
49. Micelles of fatty acids in water are organized such that the __________ faces the solvent and the __________ are directed toward the interior
carboxylic acid groups, hydrocarbon chains heads
hydrophilic heads, hydrophobic tails
hydrocarbon chains, carboxylic acid groups
both (a) and (b)
50. Cholesterolemia means
lack of functional LDL receptors
lack of functional HDL receptor
high sensitivity to fatty food intake
none of the above
51. Fatty acids break down of eukaryotes occurs in
mitochondrial matrix
cell membrane
cytosol
endoplasmic reticulum
52. VLDLs are synthesized in
blood
liver
intestine
pancreas
53. Chylomicrons are synthesized in
blood
liver
intestine
pancreas
54. How many types of lipoproteins are there?
2
6
8
5
55. Fatty acid synthesis takes place in
mitochondria
cell membrane
cytosol
endoplasmic reticulum
56. Cholestrol is the precursor of
steroid hormones
vitamin A
bile salts
both (a) and c
57. Atherosclerosis can cause blood
thinning
clotting
thickening
none of these
58. Palmitate has 16 carbon atoms with
2 double bonds
3 double bonds
One double bond
None of these
59. How many ATPs are formed during complete oxidation of palmitate?
35
96
129
131
60. The lowest energy value lipid for human nutrition is
olive oil
olestra
margarine
cardiolipih
61. How many classes of steroid hormones are there?
2
9
4
5
62. The number of water molecules consumed by the formation of phosphatidyl serine are
0
1
2
4
63. Synthesis of fatty acid takes place when
fatty acid are plentiful
carbohydrate is plentiful
carbohydrate and energy are plentiful
none of these
64. Which of the following is called milk ejection hormone?
Prolactin
Vasopressin
Oxytocin
All of these
65. How many molecules of ATPs are synthesized per NADH oxidation?
2
1
3
4
66. Why is the TCA cycle the central pathway of metabolism of the cell?
It occurs in the center of the cell
Its intermediates are commonly used by other metabolic reactions
All other metabolic pathways depend upon it
None of the above
67. In what form does the product of glycolysis enter the TCA cycle?
AcetylCoA
Pyruvate
NADH
Glucose
68. Malate-asparatate shuttle operates in
lungs and liver
heart and liver
pancreas and liver
none of these
69. Oxidation of a molecule involves
gain of electron
loss of electron
gain of proton
loss of proton
70. During cellular respiration, most of the ATP made, is generated by
oxidative phosphorylation
photophosphorylation
glycolysis
substrate-level phosphorylation
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